2006-2011 Bachelor of Pharmacy, Xinjiang Medical University, Xinjiang, China
2012-2014 Master of Biomedical Science, Rouen University, Rouen, France
Burkitkan Akbay received his master in biomedical science in Genetic, Immunology, Cancer from Rouen University, France, on the following topic: “Effects of Combined Treatment of Retinoic Acid and Arsenic Trioxide on the Differentiation of Neuroblastoma Cells” under the supervision of Dr. Isabelle Dubus and Dr. Petit Alexandre.
The main aim of his project was to study the synergistic action between Retinoic Acid and Arsenic Trioxide on the differentiation of neuroblastoma cell lines (SH-SY5Y, IGR-N-91, LAN-1) and to study the potential signaling pathways activated by these molecules. His study results showed that PIK3/AKT signaling pathway is activated by these molecules, but this activation is not necessary for the differentiation of neuroblastoma cells by using specific inhibitors of PI3K. Furthermore, he showed that the combination of these two molecules at lower concentrations has a cooperative action on the differentiation by studying the markers of neuronal cell differentiation.
After graduation from Rouen university, from 2015-2016, he worked as a research assistant within the Lam’s group and within the laboratory of immunobiology at Nazarbayev University, studying the effect of newly synthesized chemical drug on different cancer cell lines and studying the autoimmune mechanisms of Brucellosis-induced Spondyloarthritis, respectively. From April 2016 to September 2017, he worked at Heartstitch company as a medical device assembler. Currently, he is working as a teaching assistant at the department of biology at Nazarbayev University.
Signaling networks and drug target in brain cancer and leukemia