261320

Darkhan Utepbergenov, PhD


Department: Chemistry
Position: Assistant Professor and Undergraduate Program Chair
Degree:
Office: 7.112
Email: darkhan.utepbergenov@nu.edu.kz
Phone: +7 (7172) 709107

Dr. Darkhan Utepbergenov is an assistant professor in the department of Chemistry, Nazarbayev University. After graduation from the Department of Natural Sciences of Novosibirsk State University in 1996 he was awarded a scholarship from Daimler-Benz Foundation and moved to Germany to work on his Ph.D. in Research Institute of Molecular Pharmacology in Berlin. After obtaining Ph.D. degree in 2000 he worked as a postdoctoral researcher in Germany for two years and later moved to United States where he continued his research in top public universities (University of North Carolina and University of Virginia).

Dr. Darkhan Utepbergenov authored 25 scientific publications in international peer-reviewed journals and supervised dozens of undergraduate, graduate and Ph.D. students in Germany and U.S.

 

RESEARCH INTERESTS

Biochemistry, Protein chemistry, Protein tags, Bioanalytics and protein X-ray crystallography.  


 
SELECTED PUBLICATIONS 
  1. Utepbergenov, D., Hennig, P.M., Derewenda, U., Artamonov, M.V., Somlyo, A.V. and Derewenda, Z.S. (2016). Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2). PLoS One, 11, e0164343.
  2. Baker, L.E., Ellena, J.F., Handing, K.B., Derewenda, U., Utepbergenov, D., Engel, D.A., Derewenda, Z.S. (2016). Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses. Acta Crystallogr. D (Struct. Biol.), 72, 49-58.
  3. Utepbergenov D, Derewenda ZS. The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides. (2013). Biochim Biophys Acta., 1834: 1285-91.
  4. Utepbergenov D, Derewenda U, Olekhnovich N, Szukalska G, Banerjee B, Hilinski MK, Lannigan DA, Stukenberg PT, Derewenda ZS. Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor. (2012). Biochemistry., 51:6499-510.
  5. Derewenda U, Artamonov M, Szukalska G, Utepbergenov D, Olekhnovich N, Parikh HI, Kellogg GE, Somlyo AV, Derewenda ZS. Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution. (2013). Acta Crystallogr. D Biol Crystallogr., 69: 266-75.
  6. Utepbergenov D, Fanning AS, Anderson JM. Dimerization of the scaffolding protein ZO-1 through the second PDZ domain. (2006). J. Biol. Chem., 281: 24671-7.
 
Full list of publications can be found on this page.