ttokay

Tursonjan Tokay, PhD


Department: Biology
Position: Associate Professor
Degree:
Office: 7e.524
Email: tursonjan.tokay@nu.edu.kz
Phone: +7 (7172) 706610

EDUCATION

1982-1987 : MD, Medicine in Xinjiang Medical University, Xinjiang, China

2001-2005 : Ph.D. in Biology of Neuroscience at INSERM (U413), the European Institute for Peptide Research (IFRMP 23, France).


Prof. Tokay has 30 years of academic and research experience in the fields of biomedical
research, clinical research and Biomedical teaching at 4 Universities in 4 different countries:
Associate Professor of Human Anatomy at Xinjiang Medical University in China (13 years);
Doctor and Postdoc at Rouen University in France (6 year); Principal Investigator and Assistant
Professor of Physiology at Rostock University in Germany (8 years). Prof. Tokay also worked as
Deputy Director General of the Center for Life Sciences / Nazarbayev University in Kazakhstan
(2 years).
After graduation from Xinjiang Medical University, P.R. China in 1987, Prof. Tokay was
appointed for an academic position in the same University. He participated in Anatomy teaching
and several research projects of the University. In 1999, Prof. Tokay was honoured a
Scholarship from “Chinese National Scholarship Council” and sent to France to complete a PhD
program.
In 2005, after obtaining his PhD degree in Neurobiology with outstanding remarks (summa cum
Laude), he was invited by University of Rostock / Germany to participate in a national research
project granted by Federal Ministry for Education and Research of Germany. In 2009, Prof.
Tokay was appointed for a permanent academic position at the University of Rostock.
Since July 2014, Prof. Tokay has been working at the Center for Life Science at Nazarbayev
University as Deputy Director General on Science, Innovation and Academic Issues, and Head
of Institute of Bioengineering, Regenerative Medicine and Neurophysiology, respectively.


RESEARCH INTERESTS

Life Sciences – Biomedicine – Neuroscience
1. Regulation of neurotransmitter receptors and brain function in health and disease.
– To better understand the mechanisms of synaptic transmission and synaptic plasticity
– To investigate the role of glutamate receptors in learning and memory
2. Understanding the mechanisms of aging and neurodegeneration.
– To investigate the role of beta-amyloid on astrocyte and AD
– To explore the impact of Reactive Oxygen Species (ROS) on aging and
neurodegeneration.

3. Development of new therapeutic strategies to neurological disorders

– To search for molecules to prevent and treat epilepsy and other neurodegenerative
disorders


SELECTED PUBLICATIONS:

1. Mirko Rehberg, Timo Kirschstein, Xiati Guli, Steffen Müller, Marco Rohde, Tursonjan
Tokay and Rüdiger Köhling. Behavioral metaplasticity of hippocampal Schaffer collateral-
CA1 synapses is reversed in chronically epileptic rats. Neural Plasticity, 2017 (accepted) (IF:
3.608).
2. Han B, Tokay T, Zhang G, Sun P, Hou S. Eag1 K(+) Channel: Endogenous Regulation and
Functions in Nervous System. Oxid Med Cell Longev, 2017, Review. (IF: 4.49)
3. Mader F, Krause L, Tokay T, Hakenberg OW, Köhling R, Kirschstein T. P2Y receptor-
mediated transient relaxation of rat longitudinal ileum preparations involves phospholipase C
activation, intracellular Ca(2+) release and SK channel activation. Acta Pharmacol Sin. 2016
Mar 28. (IF: 2.912).
4. Mao XY, Tokay T, Zhou HH, Jin WL. Long-range and short-range tumor-stroma networks
synergistically contribute to tumor-associated epilepsy. Oncotarget. 2016 Mar 7. (IF: 6.359).
5. Guli X, Tokay T, Kirschstein T, Köhling R. Status Epilepticus Enhances Depotentiation after
Fully Established LTP in an NMDAR-Dependent but GluN2B-Independent Manner. Neural
Plast. 2016; (IF: 3.608)
6. Würdemann T, Kersten M, Tokay T, Guli X, Kober M, Rohde M, Porath K, Sellmann T,
Bien CG, Köhling R, Kirschstein T. Stereotactic injection of cerebrospinal fluid from anti-
NMDA receptor encephalitis into rat dentate gyrus impairs NMDA receptor function. Brain
Res. 2016. (IF: 2.843).
7. T. Kirschstein, T. Tokay, M. Rohde, V. Zschorlich, R. Köhling. Repetitive magnetic
stimulation (rMS) leads to NMDA receptor-dependent metaplasticity in hippocampal slices in
vitro. Clinical Neurophysiology, Volume 126, Issue 8, August 2015, Pages e85–86. (IF:
3.097)
8. Johannes Mayer, Gesine Reichart, Tursonjan Tokay, Falko Lange, Simone Baltrusch,
Christian Junghanss, Olaf Wolkenhauer, Robert Jaster, Manfred Kunz, Markus Tiedge,
Saleh Ibrahim, Georg Fuellen and Rüdiger Köhling. Reduced adolescent-age spatial
learning ability associated with elevated juvenile-age superoxide levels in complex I mouse
mutants. PLoS One. 2015 Apr 8;10(4):e0123863. (IF: 3.534).
9. Tokay T, Kirschstein T, Rohde M, Zschorlich V, Köhling R. NMDA receptor-dependent
metaplasticity by high-frequency magnetic stimulation. Neural Plast. 2014;2014:684238. (IF:
3.608).
10. Müller L, Müller S, Sellmann T, Groeneweg L, Tokay T, Köhling R, Kirschstein T. Effects of
oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage
and seizures. Epilepsy Res. 2014 Jan;108(1):90-7. (IF: 2.48).
11. Katharina Klatte, Timo Kirschstein, David Otte, Leonie Pothmann, Lorenz Müller, Tursonjan
Tokay, Maria Kober, Mischa Uebachs, Andreas Zimmer and Heinz Beck. Impaired D-serine
mediated co-transmission mediates cognitive dysfunction in epilepsy Journal of
Neuroscience, 2013, 33(32):13066-80. (IF: 6.91).
12. Tokay T, Müller L, Porath K, Köhling R, Kirschstein T. Enhanced NMDA receptor-
dependent LTP in the epileptic CA1 area via upregulation of NR2B. Neurobiol Disease,
2013 Jan 8. (IF: 5.62; shared first author).
13. Tursonjan Tokay, Raya Hachem, Olfa Masmoudi-Kouki, Pierrick Gandolfo, Laurence
Desrues, Jerome Leprince, Helene Castel, Mickael Diallo, Mohamed Amri, Hubert Vaudry,
Marie-Christine Tonon, Beta-amyloid peptide stimulates endozepine release in cultured rat
astrocytes through activation of N-formyl peptide receptors, Glia, 56 (2008) 1380-1389. (IF;
5.07).

14. Tursonjan Tokay, Marco Rohde, Sabine Krabbe, Mirko Rehberg, Roland A Bender,
Rüdiger Köhling, Timo Kirschstein, HCN1 channels constrain DHPG-induced LTD at
hippocampal Schaffer collateral-CA1 synapses, Learning & Memory, 16 (2009) 769-776. (IF:
4.08).
15. Tursonjan Tokay, Norman Holl, Timo Kirschstein, Volker Zschorlich, Rüdiger Köhling,
High-frequency magnetic stimulation induces long-term potentiation in rat hippocampal
slices, Neuroscience Letters, 461 (2009) 150-154. (IF: 2.03).
16. Tursonjan Tokay, Olfa Masmoudi, Pierrick Gandolfo, Jérôme Leprince, Georges Pelletier,
Hubert Vaudry, Marie-Christine Tonon. Beta-amyloid peptides stimulate endozepine
biosynthesis in cultured rat astrocytes. J Neurochem. 2005 Aug; 94(3):607-16(2005). (IF:
3.97).